Ultrastructural comparison of a virus from a Rhesus-monkey mammary carcinoma with four oncogenic RNA viruses.
نویسندگان
چکیده
The ultrastructure and morphogenesis of Mason-Pfizer monkey virus, isolated from a mammary carcinoma in a Rhesus monkey, was compared with those of murine mammary tumor virus, murine leukemia virus, L1210 leukemia-associated virus, and avian myeloblastosis virus. The simian virus resembled murine mammary tumor virus and the L1210 virus in that it produced intracytoplasmic particles that were enveloped during budding. It resembled L1210 virus and murine leukemia virus in budding with smooth envelopes. It differed from all the others in being more fragile. These similarities, combined with biochemical characteristics reported elsewhere in this issue, suggest that the monkey virus is an oncogenic RNA virus.
منابع مشابه
Isolation and propagation of a virus from a spontaneous mammary carcinoma of a rhesus monkey.
Virus particles morphologically similar to the known oncogenic RNA-type viruses have been isolated and cultured from a spontaneous mammary carcinoma of a rhesus monkey. The virus was initially isolated by cocultivation of tumor tis sues with monkey embryonic cell cultures but was later found to be transmissible as a cell-free filtrate. The virus is approximately 110 m^t in diameter and has a bu...
متن کاملMason-Pfizer virus RNA genome: relationship to the RNA of morphologically similar isolates and other oncornaviruses.
The 60-70S RNA of Mason-Pfizer virus (MPV) was iodinated in vitro and used in both direct and competitive molecular hybridization studies. MPV proviral sequences are present at a frequency of approximately one to two copies per haploid genome in the DNA of experimentally infected human cells. By nucleic acid competition hybridization, MPV RNA was found to be indistinguishable from the RNA of a ...
متن کاملSerological and structural properties of Mason-Pfizer monkey virus isolated from the mammary tumor of a Rhesus monkey.
We describe here serological and structural properties of a virus, Mason-Pfizer Monkey Virus (M-PMV), isolated from a simian mammary tumor. This virus is morphologically similar to the known oncogenic RNA viruses (oncornaviruses). It has a 60-70S RNA, and its replication is inhibited by actinomycin. Antisera prepared against the virus isolated by density-gradient centrifugation identify at leas...
متن کاملType D primate retroviruses: a review.
The prototype virus of the type D retroviruses is the Mason-Pfizer monkey virus (MPMV). MPMV was originally isolated from a breast carcinoma of a female rhesus monkey (an Old World monkey). MPMV is of obvious importance in that it is the only retrovirus thus far isolated from a mammary tumor of a primate and has been shown to have transforming potential for primate cells in vitro. Subsequent to...
متن کاملHypothesis for the turnover of HCV to mouse mammary tumor virus like : a novel ultrastructure prospective
Hepatitis C virus (HCV) is a rising cause of morbidity and mortality worldwide. The present work gives emphasis on the ultrastructural study of the infected liver cells and the virus–hepatocyte interactions. Increased knowledge concerning this issue may be the keystone for better management and new regimen of treatment for this disease. The material of this study consisted of 65 needle liver bi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 68 7 شماره
صفحات -
تاریخ انتشار 1971